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JERUSALEM (CNN) - In a particularly sharp blast from halfway around the world, President Bush suggested Thursday that Sen. Barack Obama and other Democrats are in favor of "appeasement" of terrorists in the same way U.S. leaders appeased Nazis in the run-up to World War II.

"Some seem to believe we should negotiate with terrorists and radicals, as if some ingenious argument will persuade them they have been wrong all along," said Bush, in what White House aides privately acknowledged was a reference to calls by Obama and other Democrats for the U.S. president to sit down for talks with leaders like Iranian President Mahmoud Ahmadinejad.

"We have heard this foolish delusion before," Bush said in remarks to the Israeli Knesset. "As Nazi tanks crossed into Poland in 1939, an American Senator declared: 'Lord, if only I could have talked to Hitler, all of this might have been avoided.' We have an obligation to call this what it is -- the false comfort of appeasement, which has been repeatedly discredited by history."

The remarks seemed to be a not-so-subtle attempt to continue to raise doubts about Obama with Jewish-Americans. Those doubts were already stoked by Sen. John McCain, the presumptive Republican presidential nominee, when he recently charged that Obama is the favored candidate of the terror group Hamas.

Obama last week called the Hamas allegation a "smear" and the Democratic presidential frontrunner also quickly lashed out Thursday at Bush's speech in Israel in a prepared statement released to CNN by his campaign.

"It is sad that President Bush would use a speech to the Knesset on the 6Oth anniversary of Israel's independence to launch a false political attack," said Obama. "It is time to turn the page on eight years of policies that have strengthened Iran and failed to secure America or our ally Israel.